What is restriction fragment length polymorphism

So why is that useful? Well, we can take advantage of this fact to actually look for differences between people if they have that restriction enzyme site or not.

So a single base difference between two people could result in either the presence or absence of that restriction site. So then, if you isolate that piece of DNA surrounding that site from two people, from one of them it will be cut by the enzyme and the other one it won't. And that results in a polymorphism, or difference between those two people. We typically see these, or we monitor these, by isolating the DNA, cutting it with that bacterial restriction enzyme, and running it on a gel using electrophoresis.

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